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Health & Safety
Yes. Psilocybin interacts with the serotonin system, so combining it with medications that affect serotonin can cause unpredictable effects or reduce efficacy.
Be cautious with:
- SSRIs and SNRIs (e.g., sertraline, fluoxetine, citalopram, venlafaxine)
- MAOIs (e.g., selegiline, moclobemide)
- Lithium, antipsychotics, or stimulant ADHD medication (e.g., amphetamine, methylphenidate)
Mixing these substances may blunt or dangerously amplify effects.
Always wait at least two full weeks after stopping such medication before considering psilocybin — and only with professional guidance.
