The Default Mode Network and Microdosing: Turning Down the Volume on the Overthinking Mind Why do so many people feel trapped in repetitive thought loops? Why do depression, anxiety, and OCD often feel like an endless replay of the same internal dialogue? Modern neuroscience points to a key brain system known as the Default Mode […]
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Bryan Johnson, Psilocybin, and the Biology of Letting Go What the most quantified psychedelic experiment ever tells us about aging, rigidity, and renewal By Joseph SantiagoFounder, Microdose Bros For decades, psychedelics have been described using language science struggles to contain: insight, ego dissolution, afterglow, rebirth. Powerful words—but slippery ones. Bryan Johnson does not traffic in […]
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Written by Joseph Santiago These Were Voted the Best Psychedelics for a First-Time Journey Harm Reduction Insights from 581 Experienced Users As interest in psychedelics grows, a record number of people are considering their first psychedelic experience — often outside clinical or medical settings. But psychedelics are powerful tools. For beginners, the choice of substance […]
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How Psilocin Calms the Brain’s Stress Circuits: What New UNC Research Reveals About Emotional Regulation Written by Joseph Santiago A new study from the University of North Carolina shows how psilocin—the active compound formed after ingesting psilocybin—calms stress-linked neurons in the central amygdala and reduces tension-driven drinking in female mice. Learn how this mechanism connects […]
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🌬️ When Psychedelics Quiet the Smoke: How Altered States May Naturally Ease Heavy Cannabis Use A new study from Paris-Saclay University shows how psychedelic experiences may naturally reduce heavy cannabis use and improve emotional flexibility — without force or therapy. The Moment That Changes Everything Sometimes, change doesn’t come through struggle or strategy. It comes […]
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