Premenstrual Syndrome and Microdosing Psilocybin

We receive questions from different users every day. Many users ask about the effect and symptoms of microdosing on the female hormone system. This also includes balancing irregular menstrual cycles, menopause, and premenstrual syndrome. There isn’t much research evidence around this topic, but we have gathered information from anecdotal reports.

Every month, women in different parts of the world rely on over-the-counter medications to help them function during their period. Premenstrual dysphoric disorder, premenstrual syndrome, and menstrual pain roughly impact physical and mental health. This is why women constantly search for remedies to these problems.

The common medications women use are contraceptive pills, SSRI antidepressants, and anti-inflammatory medications. Even though anti-inflammatory medications reduce inflammatory pain, it doesn’t handle mental and emotional challenges.

Contraceptives are also helpful, and they can manage emotional distress and pain. However, contraceptives have unpleasant side effects that make many women avoid using them. The negative side effects associated with SSRIs include loss of libido, hair loss, weight gain, and insomnia.

Today, women are widely embracing natural remedies for relief. Some of the options they embrace include hemp extracts and cannabis and microdosing psilocybin mushrooms. Continue reading to find out more about microdosing psilocybin to reduce symptoms of premenstrual syndrome and premenstrual dysphoric disorder.

Microdosing for Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) Mood Symptoms

PMS and PMDD have different psychological symptoms, and the most common are depression, fatigue, anxiety, and irritability. All of these are suggestive of an imbalance or dysfunction of the production and metabolism of serotonin. This is the main reason why many healthcare professionals prescribe SSRIs as the solution for associated mood swings. However, it’s inappropriate to prescribe antidepressants daily for symptoms that happen once a month.

Psilocybin interacts with the serotonin system, which makes them a great alternative to antidepressants. The substance binds to serotonin receptors to boost serotonin levels in the brain. The result of this is improved stamina, an overall sense of well-being, better sleep, and mood stability. Also, the positive effects of mushrooms come within 30 minutes after ingestion, which is faster than antidepressants. The interesting this is that there’s no need for prolonged dosing, which is the case with antidepressants.

Another interesting thing is that there are no serious side effects of microdosing psilocybin. However, this is only based on reports from the few research work currently available. Women across the world, in an attempt to find better alternatives, experiment with psilocybin mushrooms using different schedules and doses.

Most women discover that they have little or no PMS and PMDD symptoms following a microdose of psilocybin. With this, more women continue to go after other microdosing treatment options.

Microdosing for Premenstrual Syndrome and Premenstrual Dysphoric Disorder Pain

Headaches, fatigue, cramps, and pain are the most common symptoms of PMS and PMDD. The go-to option for most women is anti-inflammatory medications, and some women resort to high doses. However, these anti-inflammatory medications have their own side effects that can lead to chronic stomach disease and liver and kidney damage.

There are many anecdotal reports that suggest that psilocybin microdose has anti-inflammatory properties. The mechanism of this is that psilocybin can slightly restrict blood vessels and inhibit blood flow to some organs. This blood flow reduction helps to reduce inflammatory responses, thereby relieving symptoms of pain, soreness, and cramps.

In addition, the reduced blood pressure increase as a result of constricted blood vessels reduces dizziness, fainting, and nausea. Dizziness, fainting, and nausea are common symptoms of PMDD, and they are associated with low blood pressure.

Treating the Root Causes of PMS and PMDD

The main cause of PMS and PMDD remains unclear, and women don’t experience them to the same extent. There are different theories suggesting that it’s a result of sensitivity to hormones like progesterone and estrogen. Other theories suggest that it’s due to the regulation of hormones like cortisol and prolactin.

If the latter is true, then microdosing psilocybin regularly can actually help by increasing cortisol and prolactin levels. For someone suffering from PMDD and PMS, the need to find an effective treatment cannot be overemphasized. Based on small trial studies and personal experiences with different women, psilocybin is a promising treatment option. There’s a need to further research on the effectiveness of microdosing psilocybin for PMDD and PMS.


From above, it’s clear that the actual cause of the premenstrual syndrome and premenstrual dysphoric disorder pain remains unknown. Also, women don’t experience it with the same intensity. However, the fact remains that this is a condition that many women experience every month. With that, there’s a need for an effective treatment option for PMS and PMDD.

Psilocybin mushrooms offer great potential as a viable treatment for both conditions. However, there’s a need for a deeper understanding of the associated risks, dosages, and benefits of using psilocybin.

Find out more about psilocybin mushrooms, and mIcrodosing on our blog. You can also visit our Microdose Bros store to buy magic truffles, which contain psilocybin.