Truffles on Antidepressants

Many people who desire to take magic truffles are already taking one or more prescription medications. Most of them are curious to know whether it’s safe to combine their medications with psychedelic substances.

Over the past few years, psilocybin has proven to be effective in treating depression and other mental health conditions. Despite that, many substances give dangerous and undesirable interactions with psilocybin.

Microdose Bros always advises consulting with a healthcare practitioner before combining any psychedelic with your medication. However, here’s what we know about some of these medications and the risks associated with combining them with psilocybin.

How Psilocybin Works

Psilocybin is a naturally occurring compound and the active ingredient in psychedelic truffles. The substance was first discovered in 1958 and has gained different clinical research interests since then. More than 40,000 patients have received the substance without reporting any serious adverse effects.

In the stomach, psilocybin converts to its metabolite psilocin before crossing the blood-brain barrier. Upon reaching the BBB, it acts as a partial agonist on the 5-HT 2A receptors to give different effects, including altered consciousness.

Some of the common effects of the substance include colorful and unusual visuals and perceptual, affective, and cognitive changes. You can experience these effects when you ingest psilocybin in the form of truffles. Also, the psychedelic experience can be intense and last for many hours.

Magic truffles activate serotonergic receptors to cause changes in the brain systems. It also triggers a wave of excitatory activities across different perceptual centers. This gives significant cognitive effects, including alterations in the experience of time, ego-dissolution, and perceptual changes.

There is also different research evidence to show that psilocybin reduces the symptoms of depression. Also, the positive changes are proven to last longer than the effects of antidepressants. However, it’s worth mentioning that antidepressants equally work on the serotonergic system. Therefore, combining these medications with psilocybin can lead to overstimulation.

Can You Take Truffles on SSRIs?

SSRIs are short for Selective Serotonin Reuptake Inhibitors. They are the most prescribed antidepressants for depression, PTSD, anxiety disorders, and OCD. Popular SSRIs include sertraline, paroxetine, fluoxetine, escitalopram, fluvoxamine, and citalopram.

These drug substances prevent the clearance of serotonin in the brain to temporarily boost its levels. There are many cases and hypotheses suggesting that taking truffles on SSRIs can trigger serotonin syndrome. However, this risk can be mitigated with proper supervision and guidance.

Can You Take Truffles on SNRIs?

SNRIs are short for Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). They are also antidepressants that increase the levels of norepinephrine and serotonin levels in the brain. They exert similar effects to SSRIs, and popular SNRIs include milnacipran, desvenlafaxine, venlafaxine, levomilnacipran, and duloxetine.

Like SSRIs, the effects of SNRIs are expected to overlap with that of psilocybin, but there are no supporting reports. Also, there are reports showing that SNRIs can reduce the effects of psychedelics. However, it’s advisable to only combine both substances with professional guidance and support.

Can You Take Truffles on MAOIs?

MAOIs is short for Monoamine Oxidase Inhibitors (MAOIs). They are sometimes used as antidepressants in managing some anxiety disorders. MAOIs inhibit the breakdown of monoamine neurotransmitters like norepinephrine, serotonin, and dopamine. This leads to a boost in these neurotransmitters in the brain.

The common MAOIs include toloxatone, tranylcypromine, selegiline, pirlindole, phenelzine, moclobemide, metralindole, isocarboxazid, caroxazone, and bifemelane. Both MAOIs and psilocybin work via the serotonergic systems, and as such, combining them can give undesirable effects.

Also, serotonin syndrome can result from a combination of these substances, and it’s advised to avoid the combination. Although there are reports that MAOIs can reduce psychedelic effects, it’s best to start with little doses.

Can You Take Truffles on TCAs/TeCa?

TCAs is short for Tricyclic Antidepressants, while TeCA is short for Tetracyclic Antidepressants. These medications are not as common as SSRIs and SNRIs. Examples of TCAs and TeCAs are Amitriptyline, clomipramine, doxepin, lofepramine, imipramine, mirtazapine, trimipramine, mianserin, opipramol, tianeptine, many more.

The mechanism of action of TCAs and TeCAs is like that of SNRIs. They increase the levels of norepinephrine and serotonin in the brain. These substances also activate other receptors and block certain ion channels, thereby producing adverse effects.

There are different reports of the physiological effect of some TCAs and TeCAs. Some have been shown to cause death due to the effects they exert on the heart. It’s advisable to avoid combining them with psilocybin. If you’re not sure about these substances, it’s best to contact a mental health care practitioner.

Can You Take Truffles on NRI/NDRI?

NRIs represent Norepinephrine Reuptake Inhibitors, while NDRIs represent Norepinephrine-Dopamine Reuptake Inhibitors. These are substances used in managing depression and anxiety disorders. Both substances work by increasing the levels of norepinephrine, or dopamine and norepinephrine, in the brain.

Some popular NRIs and NDRIs include viloxazine, teniloxazine, reboxetine, methylphenidate, bupropion, and atomoxetine. There are no reports to show whether NRIs and NDRIs interact, but for safety, do not combine them with psilocybin.

Can You Take Truffles on SMS/SARI?

SMS represents Serotonin Modulators and Stimulators, while SARIs represent Serotonin Antagonists and Reuptake Inhibitors. These are also classes of antidepressants with similar mechanisms to SSRIs. However, these substances also activate or deactivate other serotonin receptors apart from boosting serotonin levels.

The effects of these medications on the serotonergic system are more complex. Common examples of SMS and SARIs include vortioxetine, vilazodone, and trazodone. It’s advisable not to combine these substances with psilocybin.

Can You Take Truffles on Lithium?

Lithium can be prescribed alone or used as a mediator alongside other TCAS for treating depression. The mechanism of action of the substance is unknown, but reports suggest that it’s dangerous to combine Lithium with psychedelics. This combination can cause heart failure, seizures, and death.




Are there substances that we have not included in this article? If you’re interested in knowing the interactions between psilocybin and other substances, a healthcare provider is the best person to consult.

Here’s a chart where you can find some interactions between psychedelic substances and other substances. This chart also highlights the dangers of some combinations to avoid.

Find out more about taking truffles on Microdose Bros now. Also, check out our store to buy magic truffles. We ship discreetly in Europe.