Google Star Ratings Google Star Ratings Google Star Ratings Google Star Ratings Google Star Ratings
5 Stars on Google
📦✈ We Ship to All EU Countries & UK!

Mini Cart

2-Minute on the Neuroscience: Psilocybin

Joseph Santiago

Founder - Microdose Bros

July 13, 2020

Joseph Santiago

2-Minute on the Neuroscience of Psilocybin

What is Psilocybin?

Psilocybin is a substance found in a number of mushroom species that can be ingested to cause psychoactive effects. Although psilocybin is thought to have minimal (if any) psychoactive effects, upon ingestion it is rapidly metabolized into a highly psychoactive substance called psilocin. In the above video, the effects of psilocin on the brain are discussed.

Where to find Psilocybin

Psilocybin is a substance found in a number of mushroom species that can be ingested to cause psychoactive effects. It is considered a psychedelic or hallucinogenic drug with some similarities to LSD in terms of its effects.

Psilocin and Psilocybin

Psilocybin itself is not thought to be very psychoactive, but soon after it is ingested it is metabolized into a substance called psilocin, which is highly psychoactive. Psilocybin is thus considered a prodrug, or a substance that is inactive until converted into an active drug after administration.

What does it do?

Although we have some understanding of the activity of psilocin in the brain, it is not fully understood how this activity leads to the subjective experiences people have while taking psilocybin. Regardless, it is thought that psilocin’s activity at a subtype of the serotonin receptor known as the 5-HT2A receptor is critical to the drug’s psychedelic effects.

Psilocin is thought to act as a partial agonist at the 5-HT2A receptor, which means that it binds to the 5-HT2A receptor and causes a response that is a fraction of what the natural ligand, serotonin, does. Psilocin also interacts with other targets, like different serotonin receptor subtypes, some subtypes of dopamine, histamine, and adrenergic receptors, and the serotonin transporter. The role of these other targets in the effects of psilocybin, however, is not very clear.


Like many other psychedelic drugs, repeated administration of magic truffles over multiple days leads to rapid tolerance and substantially reduced effectiveness. This tolerance is thought to be associated with the down-regulation, or decrease in the number, of 5-HT2A serotonin receptors.

Psilocybin also exhibits cross-tolerance with LSD, meaning that if someone develops tolerance to one of these drugs, they may display tolerance to the other—regardless of their history with the other drug. These types of Psychedelics are, however, not generally considered to be addictive. On top of that is thought to be safe in terms of its effects on the body.

Want to know more? Read more on our blog.  Want to stay up to date on news and facts? Sign up for our newsletter, or follow us on Instagram and Facebook.

Get MB Superfoods Cordyceps Organic Mushroom Powder today!

Discover a transformative experience at Microdose Bros and take the next step by making a purchase today! Explore our curated selection of premium psychedelic products and accessories designed to enhance your journey of self-discovery and personal growth. From magic truffles to unique blends, find the perfect option to elevate your consciousness. Don’t wait any longer – visit Microdose Bros and begin your exploration now!

Follow us Instagram
Subscribe to our YouTube Channel
Connect on Linkedin


Are you interested in shopping for microdosing products?

We at Microdose Bros are a legal Magic truffles dispensary in the center of Utrecht. We have a large selection of organic microdosing products and premium psilocybin magic truffles.

We ship discreetly within the European Union.


The content on the Microdose Bros website and the other Microdose Bros platforms is for informational and educational purposes.

It does not substitute professional medical advice or consultation with healthcare professionals.

We advise you to consult a medical professional or healthcare provider if you seek medical advice, diagnosis, or treatment.

Equally, we cannot help with the sourcing of illegal substances.

Receive Weekly updates 💌

Please join the 30,000+ members that are a part of our Microdosing Community. We send out a mailing list once a week with sometimes free giveaways, discounts, and best practices, and to learn more about psychedelics and microdosing, join today!

1 Step 1
Help us support you.
We would like to know why you’re here
What are you interested in?
FormCraft - WordPress form builder

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Select your currency
EUR Euro
Open chat
Let's chat!
Hello from the Microdose Bros Team! Curious about the fascinating world of psychedelics or microdosing? Feel free to reach out to our mushroom haven! 🍄✨ We're here to assist and guide you on your journey. Drop us a message anytime!