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Combining Exercise and Psychedelics: A New Frontier in Treating Depression and Anxiety By Joseph Santiago, Founder of Microdose Bros Depression and anxiety are no longer fringe concerns. They are among the most widespread and debilitating conditions of modern life. While traditional treatments such as SSRIs and psychotherapy have helped millions, they do not work for […]

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For decades, psychedelics like psilocybin were studied almost exclusively for their effects on the brain: altered perception, emotional breakthroughs, and relief from depression and anxiety. However, a growing body of scientific research suggests something more foundational may be happening first — inside the gut. Emerging evidence now points to psychedelics interacting with the gut–brain axis, […]

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Microdosing vs. Macrodosing: What’s the Difference and Which Is Right for You? Written by Joseph Santiago If you’re curious about psychedelics, particularly magic truffles, you’re likely wondering about the differences between microdosing and macrodosing. Each offers a distinct experience, and the right approach depends on your goals, level of experience, and desired effects. Let’s dive […]

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Understanding How Psychedelics Work: From Mystical Moments to Modern Science Have you ever wondered how psychedelics actually work right before munching on a handful of magic mushrooms? You’re not alone. For centuries, indigenous cultures across the globe—from the Mazatec people of Mexico with psilocybin mushrooms, to Amazonian shamans with ayahuasca, to Native Americans with peyote—have […]

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