Build Tolerance to Magic Truffles

Building tolerance to magic truffles is possible, but the good thing is that it doesn’t last long. This implies that after a short reset, you can continue to enjoy your psychedelic tips at their peak again. Continue reading to learn why this tolerance to magic truffles occurs and how long it takes to start tripping again. We’ll also highlight the impact of tolerance and more.

Do you still remember the first time you took magic truffles? The planning process, getting an environment for the trip, and sharing the experience. Nothing beats the whole experience, and even though people generally have different experiences, the first trip is always insightful and profound.

However, with consistent use, the potential to build a tolerance to magic truffles increases, and this can affect your trip. That is why we have taken the time to highlight the main things to know about psilocybin tolerance.

Why Does the Body Build Tolerance to Magic Truffles?

The big question is why the body builds tolerance to magic truffles. When you take truffles, psilocybin is converted to psilocin, which is a psychoactive compound. This conversion process takes place during digestion, and the compound then interacts with serotonin receptors. Serotonin receptors are in the brain, and they work on regulating perception, mood, and cognitive function.

With repeated use of magic truffles, the serotonin receptors, especially the 5HT2A receptor, become downregulated. When this happens, it causes the body to lose its sensitivity to the effects of psilocin. The effect of this is that a person may need to take higher doses to get the effects they are used to.

Dependence vs. Tolerance

Magic truffles are generally not regarded to be a drug of abuse. However, it’s important to understand the difference between tolerance and dependence. Tolerance generally describes the reduction in the effectiveness of a substance with repeated use. Dependence on the other hand describes the side effects and physical conditions of being reliant on the substance. In many cases, physical dependence is mostly linked with withdrawal symptoms. Also, tolerance is not an indicative feature of addiction or dependence.

How Long Does Magic Truffle Tolerance Last?

The good thing is that magic truffle tolerance does not last. It only takes around two weeks for the levels of serotonin to become normal. Once this happens, people can continue to experience the effects of truffles.

This implies that you can continue taking psilocybin truffles during the two weeks period. However, the effects might wane with increased frequency, and you might need to increase the dose you take. Therefore, it’s best to wait for the two weeks period to elapse before you attempt to use psilocybin again. Doing this is also a great way to ensure that your stash of truffles lasts longer.

Calculating Magic Mushroom Tolerance

At this point, you might already be wondering how you can calculate the dose to take during the two-week window. Remember that randomly increasing the dose you take can cause the trip intensity to increase, which is not ideal.

It’d interest you to note that there are online tolerance calculators that you can use. With this, you can be able to easily determine the ideal amount to consume. You only need to enter the last dose amount you take, desired amount, and the number of days. After that, the calculator will provide you with the suitable dose to take for the same effect.

Magic Truffles Cross Tolerance

In the context of psilocybin tolerance, only magic mushrooms are of relevance. Also, substances that can activate the serotonin receptors and serotonergic substances can play a role. Most psychedelic substances on the market today turn out to be serotonergic substances.

LSD is a psychedelic substance that can interact with serotonin receptors like psilocybin. This implies that it also has the potential to induce tolerance, even for someone that hasn’t taken truffles. The two weeks rule also applies in the case of cross-tolerance, after which the base level is restored.

Microdosing to Overcome Tolerance to Magic Truffles

Many users now microdose with hopes that they will be able to manage tolerance to magic truffles. Interestingly, there have been many promising results from this strategy. Basically, microdosing involves taking a little dose of psilocybin according to a microdosing protocol. The amount you take when microdosing is generally enough to produce high feelings.

Also, because you’ll be taking it for many weeks, you’ll have an almost constant level of psilocybin in the body, and this produces a new base level. With that, you’ll be more likely to increase the dose you take with time. However, most microdosing protocols, like Stamets and Fadiman, suggest resetting for a period of two to four weeks after each cycle.

It’s worth mentioning that there are many cycles to consider, among which include age, weight, and genetics. There are no profound results highlighting whether microdosing can bypass tolerance. However, there are many studies that indicate its potential to achieve this.

Taking a Break from Truffles to Reset Tolerance

With everything above, the most effective way to break tolerance is to reset for two weeks. This also applies to microdosing. The psychedelic experience can be profound, but the reset period is a great way to regulate your body and reduce tolerance. It will also allow you to feel revitalized and appreciate the psychedelic effects more.

Increasing the dose you take is never a good thing, and its effect only becomes more detrimental. Also, taking it too low only causes a diminished effect. With that said, the art of microdosing and taking truffles should be considered a special one.


Building tolerance to truffles is very common, but the good thing is that you can come out of it. While many people resort to increasing the dose they take to get the desired effects, the best option is to reset for a period of two weeks. After this, you can resume taking truffles again to get the effect you desire, even without increasing the dose.

Find out more about psilocybin, microdosing, and magic truffles on the Microdose Bros blog. You can also visit our online store to buy magic truffles to start microdosing for its benefits.