In the 1980s, the AIDS epidemic helped to turn the war on drugs away from cannabis because of its potential medicinal benefits.

In 2021, another surge was happening in the field of psychedelics. Microdosing offers promising potential outcomes for those with various mental health conditions, including depression.

When people take microdoses of psilocybin products, such as magic truffles, there can be boosts to productivity, mood, and emotional stability. Some know their treatment plan already includes antidepressants, SSRIs, and other prescriptions.

Is it safe to take magic truffles and antidepressants simultaneously?

Over 12% of People 12 and Older Take Antidepressants

About one in ten people in the developed world currently take a prescribed antidepressant. The most common type given to people is called an SSRI.

SSRI stands for “selective serotonin reuptake inhibitor.” Although doctors typically prescribe SSRIs for severe or persistent cases of depression, they can also be offered as a first treatment choice in some situations.

As part of their treatment plan, many who have SSRIs also engage in talking therapeutics, such as cognitive-behavioral therapy.

People with severe cases of depression are often found with abnormally low serotonin levels. The goal with the prescription medication is to increase this neurotransmitter to restore previous functionality.

Psilocybin and SSRI medicines can increase the serotonin the body produces from the L-tryptophan amino acid. When too much of it gets made, the “Serotonin Syndrome” condition occurs.

It is possible to experience the effects of Serotonin Syndrome by overdosing on prescribed SSRI medication. Roughly 15% of the people who take too many antidepressants experience this health issue, but an accurate statistic isn’t available because up to 85% of physicians lack awareness of this toxicity concern.

Although the symptoms of Serotonin Syndrome are often mild, it can become a life-threatening condition. The issues include autonomic hyperactivity, agitation, delirium, muscle twitching, tremors, and hyperthermia.

The goal of taking an SSRI is to let the body’s systems attempt to self-regulate the serotonin receptors to restore their original functionality. It’s a way to encourage healing.

When the receptors get reformed by SSRI, the way the body interacts with psilocybin and magic truffles can change.

Psilocybin Receives Classification as a Tryptamine 

The primary concern with magic truffles is that the psilocybin they contain is classified as a “tryptamine.”

Tryptamines are a broad class of serotonin-based hallucinogens. They can produce robust changes in mood, thought, and sensory perception. Well-documented use of magic mushrooms containing this compound date back to the Aztec empire, with older civilizations also embracing its use.

Many psilocybin treatment retreats refuse to accept visitors who take SSRIs. Even if someone has been off the medication for six weeks, the receptor changes can still be present and create risk factors for one’s health.

Most accounts suggest that Microdosing with SSRIs creates a “blunted” response. That means the positive effects from the magic truffles may not have the same strength for someone taking antidepressants as someone who isn’t taking the medication.

Some doctors are concerned that even SSRI use in a person’s lifetime could hinder the potency of magic truffles or other psychedelic-assisted treatments.

Other Medications Impact Serotonin Production

Several prescription medications create potential issues that could lead to Serotonin Syndrome development when overdosed or taken with other items. Although there is no empirical data currently available to suggest an interaction between antidepressants and psychedelics, the fact that both increase serotonin production is enough to proceed with caution.

Here are some of the drugs associated with Serotonin Syndrome.

   Drug Category:

Drugs Associated with Serotonin Syndrome


Fluoxetine, Fluvoxamine, Citalopram, Sertraline, and Paroxetine

  Antidepressant Drugs

Trazodone, Clomipramine, Buspirone, Nefazodone, and Venlafaxine

  Monoamine Oxidase Inhibitors

Clorgiline, Isocarboxazid, Moclobemide, and Phenelzine




Meperidine, Pentazocine, Tramadol, and Fentanyl

   Migraine Medication


  Bariatric Medication



Linezolide, ritonavir

  OTC Medication


  Antiemetic Agents

Granisetron, Metoclopramide, and Ondansetron

  Illicit Drugs

MDMA, LSD, Harmine, Harmaline, Meth

Since psilocybin produces a similar result as the medications or illicit drugs in the table above, it’s only reasonable to suggest that mixing a psychedelic with anything that increases serotonin neurotransmission could be potentially dangerous.

Why Does SSRI Medication Reduce the Effectiveness of Psilocybin?

Most psychedelics get metabolized by a liver enzyme called CYP2D6. When people take SSRI medication, one of the drug’s side effects is inhibiting enzyme production.

That means there isn’t as much CYP2D6 available to metabolize the psilocybin, resulting in an increase of the compound in a person’s bloodstream. When SSRIs are taken simultaneously with magic truffles, the serotonergic substances rise.

This issue is why the general recommendation is to reduce or eliminate antidepressants before trying Microdosing or psychedelic therapy.

It takes approximately five weeks for the antidepressant levels to reduce enough for the effects of psilocybin to become beneficial through Microdosing.

Some people may find low-dose SSRI treatments and Microdosing magic truffles effective. The two elements may combine to create a more significant serotonin boost when working together, although no research is available to confirm or deny such a conclusion.

When people have taken SSRI medication chronically, evidence suggests that long-term effects from psilocybin and other psychedelics are reduced because of the down-regulation of the affected 5-HT2A receptors.

Not everyone agrees with that assessment. Dr. Matthew Johnson, a psychiatry and behavioral sciences professor at Johns Hopkins University, has not seen a diminished response.

Dr. Johnson admits that anyone with chronic SSRI use would need to be off the medication for several weeks before having a psychedelic treatment session. He also notes that they haven’t specifically analyzed the blunted response.

“I doubt if there is anything substantial as we’ve seen many cases of powerful sessions with folks in that situation,” he said in a 2020 interview.

Some researchers suggest that psychedelics like psilocybin and SSRI medications modify the body’s systems in two different ways. Instead of leading to a problem like Serotonin Syndrome, this result could lead to complementary therapeutic options.

In 2017, a study looked at how antidepressants and SSRIs enhance a pathway called 5-HT1AR, while psychedelics like psilocybin enhance the 5-HT2AR pathways.

SSRI Interactions and Cautions to Consider 

Selective serotonin reuptake inhibitors aren’t an appropriate medication for everyone. They’re known to cause problems if you have other health issues to manage.

These antidepressants can also cause interactions when taken with other medications.

An SSRI might not be suitable if you have any of the following medical conditions.

  • Type 1 or Type 2 Diabetes
  • Narrow-Angle Glaucoma
  • Liver, Heart, or Kidney Disease
  • Bleeding Disorders
  • Bipolar Disorder, especially for those in a manic phase.

If SSRIs are inappropriate in those circumstances, it might be better to consider Microdosing with magic truffles. This activity’s creativity enhancements and other benefits can boost serotonin levels in small ways to create a better internal balance.

Anyone diagnosed with epilepsy should not take an SSRI unless well-controlled condition. Even then, it should be stopped if the symptoms worsen.

Some medications interact with SSRIs, so you’d want to avoid taking them and magic truffles simultaneously. The most common problems involve NSAID products, such as naproxen, ibuprofen, and diclofenac.

To prevent unwanted symptoms, people must also avoid low-dose aspirin, theophylline for asthma, and MAOIs.

Before taking magic truffles or mixing medication with SSRIs, it’s best to read the patient information that comes with over-the-counter or prescription products.

Do Foods and Beverages Interact with Antidepressants and Magic Truffles?

When you want to experience the best results from Microdosing, the Lemon Tek method can be a great way to use your magic truffles.

That methodology will work if you take an SSRI unless you create a tea from the magic truffles. You’d want to soak them in citrus juice only.

Some SSRIs are known to enhance caffeine’s effects on the body. If you have coffee, tea, cola, or energy drinks while taking the medication and magic truffles, the symptoms might include insomnia, restlessness, extreme nausea, and heart palpitations.

It is not usually recommended to drink alcohol while taking SSRIs. That combination can increase feelings of fatigue or drowsiness. Some people even report that mixing the two can worsen their depression-like symptoms.

Other Factors to Consider When Taking SSRIs and Using Magic Truffles

SSRI medications are known to cause blurred vision, drowsiness, and dizziness. These symptoms can be especially strong during the first few days when taking them. It’s better to avoid using magic truffles during this time because the body’s response could be overwhelming.

If you experience any of those symptoms, avoiding driving, using machinery, or operating heavy tools is best.

For most people, the unwanted symptoms or side effects are temporary. If they persist, your doctor will want to know that potential alternatives can be explored.

Since Microdosing alone doesn’t come with the same risk factors, it might be worth exploring the option of starting with magic truffles. Instead of jumping right into SSRIs or other antidepressants, mild cases might see positive reactions to the low levels of psilocybin.

Is It Safe to Microdose Magic Truffles While Taking Antidepressants?

It is impossible to say with certainty that the relationship between serotonin toxicity and taking SSRIs with psychedelics is a legitimate concern.

It’s also impossible to say that psilocybin and SSRIs interact with two different receptor pathways, creating a guaranteed safe experience.

Although Microdosing and taking a low-dose SSRI would be the safest combination for using these two items simultaneously, the fact remains that our current knowledge in this area is insufficient to offer an accurate risk assessment.

It would be fair to say that taking two items that increase serotonin is potentially risky.

Since SSRI medication limits the liver enzyme production that metabolizes the compounds in magic truffles, it’s also fair to say that creative results or enhanced productivity might not be available at the expected levels when taking both items.

Even a person’s medical history, overall health, and dietary factors play a role in medication metabolization.

We’re not doctors. All we can offer is a look at the current information so that you can decide if magic truffles are worth taking while using antidepressants or SSRIs.

Only you are responsible for your choices. We provide access to high-quality magic truffles here at Microdose Bros. Buy magic truffles now and get a discount.

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