Understanding the Difference Between Microdosing and Macrodosing

Psychedelics have long held a mystical and therapeutic allure, capturing the curiosity of many for their potential to unlock new dimensions of consciousness and healing. At Microdose Bros, we’ve seen a growing interest in two primary approaches to using these substances: microdosing and macrodosing. Though they involve the same substances, their effects, applications, and experiences are vastly different. Let’s explore these distinctions in depth.

The Essence of Microdosing

Definition and Approach: Microdosing involves the consumption of very small, sub-perceptual amounts of a psychedelic substance, such as LSD or psilocybin. Typically, a microdose is about 1/10th to 1/20th of a full dose, often ranging from 5-20 micrograms of LSD or 0.1-0.3 grams of dried psilocybin mushrooms.

Purpose and Effects: The aim of microdosing is not to induce a full-blown psychedelic experience, but to subtly enhance daily functioning. Users often report improvements in mood, creativity, focus, and overall well-being without the hallucinogenic effects that characterize higher doses. It’s a practice that fits seamlessly into daily life, providing a gentle boost rather than a profound trip.

Integration and Routine: Microdosing is often integrated into a routine, with users typically dosing several times a week with breaks in between. These breaks, or “afterglow days,” are crucial for allowing the subtle benefits to integrate into one’s life, fostering a steady, incremental path to personal growth and wellness.

The Power of Macrodosing

Definition and Approach: Macrodosing, on the other hand, involves taking a significantly larger dose of a psychedelic substance, enough to produce intense psychoactive effects. These doses generally fall within the range of 100-200 micrograms of LSD or 2-5 grams of dried psilocybin mushrooms.

Purpose and Effects: A macrodose is designed to induce a deep, transformative experience. Users often encounter vivid visual and auditory hallucinations, altered perceptions of time and space, and profound introspective insights. This level of dosing is typically used for therapeutic purposes, such as addressing deep-seated trauma, depression, or addiction, and is often conducted in a ceremonial setting with a trained guide or shaman.

Preparation and Integration: Preparing for a macrodose involves extensive preparation, often taking months to find the right guide and setting. The experience itself can be emotionally intense and requires careful integration afterward. This process of integrating the insights and emotions uncovered during a macrodose can be a lifelong journey, demanding ongoing reflection and support.

Comparing Microdosing and Macrodosing

Dosage and Perception: Microdosing involves small, almost imperceptible doses aimed at enhancing everyday life, while macrodosing involves high doses intended to provoke significant, life-changing experiences.

Intended Outcomes: Microdosing aims for incremental improvements in mental and emotional well-being, whereas macrodosing seeks deep psychological and spiritual breakthroughs.

Context and Application: Microdosing is easily incorporated into daily routines without disrupting normal activities. In contrast, macrodosing is often reserved for specific, carefully planned sessions, usually in therapeutic or ceremonial contexts.

Support and Safety: Microdosing does not typically require supervision, whereas macrodosing should always be conducted with the support of an experienced guide or shaman to navigate the intense experience safely.

Pros and Cons


  • Affordability: Microdosing is more cost-effective, making it accessible without the high expenses of guided macrodose ceremonies.
  • Convenience: It does not require the involvement of a shaman or healer, nor does it necessitate taking time off from daily responsibilities.
  • Integration: The practice inherently includes rest days to assimilate the benefits gradually and sustainably.


  • Profound Insights: Macrodosing offers the opportunity to deeply explore consciousness, restructure beliefs, and access buried memories.
  • Therapeutic Potential: It can lead to significant emotional release and psychological healing, facilitated by experienced practitioners.
  • Transformative Experiences: These sessions can act as pivotal moments, offering a fresh perspective on life and deep personal insights.

Final Thoughts

Both microdosing and macrodosing have unique benefits and applications, serving different needs and goals. At Microdose Bros, we believe in the importance of understanding these practices deeply and using them responsibly. Whether you’re gently sipping from the cup of daily enhancement or riding the transformative wave of a profound journey, each path offers valuable opportunities for growth and healing.

As we continue to explore the vast potential of psychedelics, remember to proceed with curiosity, respect, and mindfulness. Always prioritize safety and integration, and seek guidance when needed. The afterglow of these practices is real and can illuminate your path in surprising and beautiful ways.

Stay informed, trust your instincts, and journal your experiences. Happy exploring!

Best regards,

Joseph Santiago
Founder, Microdose Bros

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