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Psilocybin and Depression: What the UK’s Landmark Trial Actually Found For most of the last fifty years, psilocybin has lived in a strange limbo. Ancient medicine to some cultures, a countercultural symbol to others, a banned substance to governments, and — for a very long time — almost impossible to study seriously. That’s shifting again. […]

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How an ancient sacred sacrament became one of the most talked-about substances in modern science, wellness, and technology Thousands of years before Silicon Valley executives began discussing microdosing over coffee, before neuroscientists placed psilocybin users inside MRI machines, and long before the psychedelic renaissance captured headlines around the world, magic mushrooms were already considered sacred. […]

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Written by Joseph Santiago Exploring the science behind psychedelics, cannabis use disorder, and my personal journey after nearly 30 years of daily cannabis use. Many people start using cannabis for good reasons. Some use it to relax after a stressful day. Others use it to support sleep, reduce discomfort, spark creativity, or simply enjoy a deeper […]

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Some people call it a “bad trip.”Carl Jung might have called it shadow work. Psychedelics and the shadow self are deeply connected. Psychedelics have a way of bringing hidden parts of ourselves to the surface – the emotions, memories, fears, and traits we usually avoid. Sometimes this can feel uncomfortable or confronting, but these experiences […]

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How Psilocin Calms the Brain’s Stress Circuits: What New UNC Research Reveals About Emotional Regulation Written by Joseph Santiago A new study from the University of North Carolina shows how psilocin—the active compound formed after ingesting psilocybin—calms stress-linked neurons in the central amygdala and reduces tension-driven drinking in female mice. Learn how this mechanism connects […]

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