Apart from the well-being benefits that microdosing offers, there is a range of reported effective medical applications. ADHD, cluster headaches, and depression are some of the most common medical applications of microdosing. Results from Dr. James Fadiman’s research show that microdosing offers the following medical benefits:

  • Hormonal imbalance (PMDD, menopause)
  • Traumatic Brain Injury
  • Burnout
  • Social anxiety
  • Allergies
  • Recovery from stroke
  • Addiction
  • Hair loss
  • Premenstrual syndrome (PMS)
  • Eating disorders
  • Obsessive-compulsive disorder (OCD)
  • Migraines
  • Cluster headaches
  • ADD and ADHD

It’s worth mentioning that these are mostly based on anecdotal evidence. There’s a need for further clinical studies to further elucidate the potential for microdosing and the positive impact it has on the aforementioned ailments.

Microdosing and Depression

Participants in Fadiman’s study al reported significant relief in their depressive symptoms. Depression is a disorder that affects people, and a feeling of persistent sadness and loss of joy characterizes it. Another study shows that there are many who successfully use microdosing to fight depression.

Reports from a patient with Parkinson’s disease also highlight that even though their Parkinson’s symptoms didn’t improve after microdosing LSD, they enjoyed significant improvement in their underlying depression. It’s worth noting that the data from Fadiman’s research are mostly from subjects with a one-month microdosing plan.

Microdosing and Cluster Headaches

Microdosing offers multiple promises for treating different health conditions, including cluster headaches. Most people describe cluster headaches as an unbearable head pain that is often more intense than kidney stones or even childbirth. Dr. Fadiman also reports patients that were able to treat cluster headaches by microdosing LSD.

Research by a platform dedicated to patients with cluster headaches shows that most treatments were unsuccessful. However, more than 80% of patients enjoyed relief in their symptoms through magic mushrooms, magic truffles, 1cp-LSD, or LSD. The doses that provided the relief they enjoyed are higher than a microdose, but there is also evidence to show that microdosing these substances are equally effective.

Fortunately, research to further explore microdosing as a treatment option for cluster headaches has started in Canada and the US. It is expected that this will show the effectiveness of microdosing psychedelics for different disorders.

Microdosing and ADHD/ADD

Because of the ability of microdosing psychedelics to impact focus, they are a suitable replacement for ADHD medications and other cognitive enhancers. One of the participants in Fadiman’s study reported that microdosing psychedelics improved his life. According to Albert Hofmann, if LSD were legal, it would have been a perfect substitute for Ritalin or Adderall, both of which are highly addictive. Today, there are people who now microdose legal variants of LSD for ADHD and ADD.

Are There Any Risks to Combining Microdosing with Medication?

Fadiman’s research shows that many medications and supplements do not cause any side effects when combined with microdosing. However, this is only from fieldwork research involving 1850 people who microdose magic mushrooms, LSD, or 1p-LSD, on their own accord and shared their findings, insights, and experiences. It’s worth noting that there are also certain substances that should not be combined together with microdosing.


Research to further explore the medical applications of microdosing is desperately needed. For most people, conventional medications are insufficient and come with many side effects. Even though there are reports that microdosing can offer the solution they require, there’s still a need for deeper clinical studies by scientific communities. To facilitate this research, the substances will need to be made legally available to health practitioners to allow people to find relief from the symptoms they experience.

The bottom line is that there are many physical and mental health conditions that microdosing shows promise and could be a vital option for people to improve their lives globally. However, the illegal status of these substances remains a challenging factor that affects the application of these substances. Before you microdose on any substance, we recommend consulting with a health practitioner about your mental and physical health.

There’s so much for you to learn about Microdosing and the different types of psychedelics on Microdose Bros. Visit our online blog to learn more about the possible health benefits of microdosing psilocybin and other substances. Alternatively, you can visit our online store to buy your magic truffles. We have different products and offer discreet delivery in all of Europe.